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ASAACAcetylsalicylic Acid versus Anticoagulants study |
| Authors: |
Weber MAJ, Hasford J, Taillens C, Zitzmann A, Hahalis G, Seggewiss H et al |
| Titles: |
Low-dose aspirin versus anticoagulants for the prevention of coronary graft occlusion |
| References: |
Am J Cardiol 1990;66:1464-8 |
| Disease: |
Coronary artery disease, coronary graft occlusion |
| Purpose: |
To compare the occlusion rates of grafts or bypass vessels, perioperative blood loss and clinical results in patients treated with platelet inhibitors or anticoagulant therapy after coronary artery bypass |
| Study Design: |
Randomised, open, parallel-group |
| Follow-up: |
3 months |
| Patients: |
235 patients (122 aspirin and 113 anticoagulant) |
| Treatmentregimen: |
Aspirin, 100 mg/day, started 24 h before coronary bypass surgery, or heparin in a constant dose of 10,000 U/24 h, started 6 h after surgery, plus phenprocoumon 48 h after surgery. Heparin was discontinued after a prothrombin of 30% had been reached |
| Results: |
22% of 218 vein graft distal anastomoses in the aspirin group and 29% of 272 in the anticoagulant group were occluded. At least one occluded distal anastomosis was present in 38% of 74 patients in the aspirin group and in 39% of 86 in the anticoagulant group. For grafts with endarterectomy, the occlusion rate was lower in the aspirin group (12% vs 22%; p = 0.05). Perioperative blood loss in the aspirin group was 1211 ± 814 ml in the first 48 h, compared to 874 ± 818 ml in the anticoagulant group (p = 0.001) | |
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