| Search |
|
| Menu |
You are not logged in [Login]
|
|
CABADASPrevention of Coronary Artery Bypass graft occlusion by Aspirin, Dipyridamole, and Acenocoumarol/phenprocoumon Study |
| Authors: |
(a) van der Meer J, Hillege HL, Kootstra GJ, Ascoop CAPL, Pfisterer M, van Gilst WH, Lie KI
(b) Mulder BJM, van der Doef RM, van der Wall EE, Tijssen JGP, Piek JJ, van der Meer J, Dunning AJ |
| Titles: |
(a) Prevention of one-year vein-graft occlusion after aortocoronary-bypass surgery: a comparison of low-dose aspirin, low-dose aspirin plus dipyridamole, and oral anticoagulants
(b) Effect of various antithrombotic regimens (aspirin, aspirin plus dipyridamole, anticoagulants) on the functional status of patients and grafts one year after coronary artery bypass grafting |
| References: |
(a) Lancet 1993;342:257-64
(b) Eur Heart J 1994;15:1129-34 |
| Disease: |
Angina pectoris |
| Purpose: |
To compare the efficacy and safety of low- dose aspirin, aspirin plus dipyridamole and oral anticoagulants in the prevention of vein-graft occlusion during the first year after aortocoronary bypass surgery |
| Study Design: |
Randomised, double-blind, placebo- controlled for the aspirin groups, open for the oral anticoagulant group |
| Follow-up: |
1 year |
| Patients: |
948 patients, aged = 70 years, with angina requiring aortocoronary bypass surgery with saphenous vein grafts |
| Treatmentregimen: |
Aspirin, 50 mg/day, started after surgery, or dipyridamole, 5 mg/kg/24 h iv for 28 h from the day preceding surgery, followed by 200 mg/day bid plus aspirin, 50 mg/day, from midnight on the day of surgery, or either fixed dose of nicoumalone, 4 mg, or ph |
| Results: |
Occlusion rate of distal anastomoses was 11 % in the aspirin plus dipyridamole group, 15% in the aspirin group and 13% in the oral anticoagulation group. Clinical events occurred in 20.3% of patients receiving aspirin plus dipyridamole, compared to 13.9% of the aspirin group and 16.9% of the oral anticoagulants group. Addition of dipyridamole to 50 mg/day aspirin did not significantly improve patency rates and increased the overall clinical events rate. Oral anticoagulants provided no benefit as compared to aspirin. In a subgroup of 127 patients, there were no differences in symptoms of angina pectoris or exercise capacity between the three groups | |
|
