SPIRITStroke Prevention In Reversible lschemia Trial |
| Authors: |
Algra A |
| Titles: |
SPIRIT: Bleeding complications in patients after cerebral ischemia treated with anticoagulant drugs |
| References: |
Stroke 1997;28:231 |
| Disease: |
Transient ischaemia or ischaemic stroke |
| Purpose: |
To compare the efficacy and safety of daily aspirin and anticoagulant drugs in patients after a transient ischaemic attack or minor ischaemic stroke |
| Study Design: |
Randomised, open, blind assessment |
| Follow-up: |
Planned 2.9 years; fulfilled 1200 person- years |
| Patients: |
Aim 3000 patients (1243 randomised) |
| Treatmentregimen: |
Aspirin, 30 mg/day, or anticoagulant drugs to give an international normalised ratio of 3.0-4.4 |
| Results: |
There was an excess of primary outcome events (death from all vascular causes, stroke, MI, or major bleeding complications) in the anticoagulant therapy group, 54/616 vs 26/627 in the aspirin group |
